New Massage Research



Great new research in how Massage Therapy helps with rehabilitation.

New Massage Research: Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage

Sci Transl Med 1 February 2012:
Vol. 4, Issue 119, p. 119ra13
Sci. Transl. Med. DOI: 10.1126/scitranslmed.3002882


Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage

  1. Justin D. Crane1,
  2. Daniel I. Ogborn2,
  3. Colleen Cupido1,
  4. Simon Melov3,
  5. Alan Hubbard4,
  6. Jacqueline M. Bourgeois5 and
  7. Mark A. Tarnopolsky1,6,*



Massage therapy is commonly used during physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. Although there is evidence that massage may relieve pain in injured muscle, how massage affects cellular function remains unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of 11 young male participants after exercise-induced muscle damage. Muscle biopsies were acquired from the quadriceps (vastus lateralis) at baseline, immediately after 10 min of massage treatment, and after a 2.5-hour period of recovery. We found that massage activated the mechanotransduction signaling pathways focal adhesion kinase (FAK) and extracellular signal–regulated kinase 1/2 (ERK1/2), potentiated mitochondrial biogenesis signaling [nuclear peroxisome proliferator–activated receptor γ coactivator 1α (PGC-1α)], and mitigated the rise in nuclear factor κB (NFκB) (p65) nuclear accumulation caused by exercise-induced muscle trauma. Moreover, despite having no effect on muscle metabolites (glycogen, lactate), massage attenuated the production of the inflammatory cytokines tumor necrosis factor–α (TNF-α) and interleukin-6 (IL-6) and reduced heat shock protein 27 (HSP27) phosphorylation, thereby mitigating cellular stress resulting from myofiber injury. In summary, when administered to skeletal muscle that has been acutely damaged through exercise, massage therapy appears to be clinically beneficial by reducing inflammation and promoting mitochondrial biogenesis.


Myosense Wellness offers a variety of types of Massage Therapy to help with your rehabilitation and overall well being. From Rolf Structural Integration (rolfing), Thai Massage, Sports Massage, and deep tissue. Book online


%d bloggers like this:
search previous next tag category expand menu location phone mail time cart zoom edit close